The key word in this passage is reconciliation. Reconciliation means to settle one’s differences, to make peace between enemies, or to declare a truce. Through the work of Christ on the cross, Jesus has brought humanity and God together again. Reconciliation refers to a restored relationship between God and the lost world.
God has reconciled us to himself through Christ. God has also given us the ministry of reconciliation
2 Corinthians 5:17-21 Therefore, if anyone is in Christ, he is a new creation; the old has passed away, and see, the new has come! 18 Everything is from God, who has reconciled us to himself through Christ and has given us the ministry of reconciliation. 19 That is, in Christ, God was reconciling the world to himself, not counting their trespasses against them, and he has committed the message of reconciliation to us. 20 Therefore, we are ambassadors for Christ, since God is making his appeal through us. We plead on Christ’s behalf: “Be reconciled to God.” 21 He made the one who did not know sin to be sin for us, so that in him we might become the righteousness of God.
God does not have to be reconciled to humanity, because Christ accomplished that on the cross. It is sinful man who must be reconciled to God. “Religion” is man’s feeble effort to be reconciled to God, any and every effort is bound to fail. The Person who reconciles us to God is Jesus Christ, and the place where He reconciles us is His cross.